Reports

Macroglobulin Structure: Variable Sequence of Light and Heavy Chains

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Science  03 Jul 1970:
Vol. 169, Issue 3940, pp. 56-59
DOI: 10.1126/science.169.3940.56

Abstract

The variable regions of the light and heavy chains on the same macroglobulin (immunoglobulin M) molecule are no more related in amino acid sequence than are the variable regions of the light and heavy chains of different immunoglobulin molecules. Subgroups of µ chains are similar in their variable sequence to subgroups of γ chains.