Reports

Quinacrine: Mechanisms of Antimalarial Action

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Science  31 Jul 1970:
Vol. 169, Issue 3944, pp. 492-493
DOI: 10.1126/science.169.3944.492

Abstract

Two new interesting modes of action of quinacrine have been discovered. The first concerns a dose-related inhibition of uptake of [8-3H] adenosine into host cells of parasitized blood. Second, the drug inhibits the incorporation of tritiated adenosine triphosphate primarily into RNA but also into DNA of the erythrocyte-free malarial parasite Plasmodium berghei.