Serum Hepatitis Antigen (SH): Rapid Detection by High Voltage Immunoelectroosmophoresis

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Science  07 Aug 1970:
Vol. 169, Issue 3945, pp. 593-595
DOI: 10.1126/science.169.3945.593


An immunoelectroosmophoretic technique for rapid detection of the antigen (SH) associated with the serum hepatitis virus has been devised. The technique maintains the specificity characteristic of the Ouchterlony gel-diffusion method, yet detects in 1 to 2 hours one-tenth the amount of antigen required for gel diffusion. The test has immediate application to blood-banking practice since it permits the screening of such labile products as platelets and fresh whole blood, and the detection of antigen in additional serums negative by the Ouchterlony technique.