Reports

Immunoglobulin M Heavy Chain Disease: Intracellular Origin of the Mu Chain Fragment

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Science  21 Aug 1970:
Vol. 169, Issue 3947, pp. 770-773
DOI: 10.1126/science.169.3947.770

Abstract

Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.