Hemolysis Near an Ultrasonically Pulsating Gas Bubble

Science  28 Aug 1970:
Vol. 169, Issue 3948, pp. 869-871
DOI: 10.1126/science.169.3948.869


A small volume of an erythrocyte suspension was subjected to the action of a manipulated gas bubble set into stable oscillation at 20 kilohertz. Release of hemoglobin occurred when the oscillation amplitude exceeded a critical threshold. Hydrodynamic stresses resulting from acoustically induced small-scale eddying motion near the bubble may be the mechanism of hemolysis.