Oxychlordane, Animal Metabolite of Chlordane: Isolation and Synthesis

Science  11 Sep 1970:
Vol. 169, Issue 3950, pp. 1087
DOI: 10.1126/science.169.3950.1087


Oxychlordane (C10H4Cl8O), a minor heretofore unidentified metabolite, was isolated from fat of pigs on diets heavily dosed with pure isomers of the insecticide, chlordane (C10H6Cl8). Chemical and spectroscopic evidence provides bases for proposal of structure of the metabolite as 1-exo-2-endo-4,5,6,7,8,8-octachloro-2,3-exo-epoxy-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene.