Turnover of the Brain Specific Protein, S-100

Science  25 Sep 1970:
Vol. 169, Issue 3952, pp. 1333-1334
DOI: 10.1126/science.169.3952.1333


Rats were killed after intraventricular administration of [3H]leucine, and the turnover rates of total soluble proteins and of the brain specific S-100 protein were determined. The half-life of S-100 was estimated to be 16 days. The S-100 protein, thus, has a turnover not unlike that of the average water-soluble protein of brain.