Antitumor Activity in Mice of Tentacles of Two Tropical Sea Annelids

Science  09 Oct 1970:
Vol. 170, Issue 3954, pp. 181-183
DOI: 10.1126/science.170.3954.181


Crude extracts of tentacles of two polychaetous annelids completely inhibit growth of Erlich ascites tumor in 60 to 100 percent of treated mice. Dialyzed extracts of one of these annelids, Lanice conchilega, show activity in the retentate after pronase digestion, suggesting that antitumor activity is associated with a nonprotein component of the crude tentacle extract.