Histamine Production by Transplantable Argyrophilic Gastric Carcinoid of Praomys (Mastomys) natalensis

Science  23 Oct 1970:
Vol. 170, Issue 3956, pp. 454-455
DOI: 10.1126/science.170.3956.454


A transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis contained appreciable amounts of histamine. Dialyzed, microsome-free supernatant of tumor tissue produced definite amounts of histamine in the presence of L-histidine and pyridoxal phosphate. These findings may relate to hypersecretion of gastric acid and formation of multiple ulcers in the stomach and duodenum of Mastomys bearing carcinoids.