Reports

Substrate-Induced Conjugation of Bilirubin in Genetically Deficient Newborn Rats

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Science  30 Oct 1970:
Vol. 170, Issue 3957, pp. 555-556
DOI: 10.1126/science.170.3957.555

Abstract

Bilirubin appears to induce its own conjugation with glucuronide. Bilibrubin uridine diphosphate-glucuronyltransferase activity is relatively high at birth in heterozygous offspring of permanently jaundiced female rats. The postnatal development of the transferase is accelerated in hyperbilirubinemic heterozygotes.

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