Reports

Transfer of Interferon-Producing Macrophages: New Approach to Viral Chemotherapy

+ See all authors and affiliations

Science  20 Nov 1970:
Vol. 170, Issue 3960, pp. 854-856
DOI: 10.1126/science.170.3960.854

Abstract

Mice were protected from infection with Semliki Forest virus and encephalomyocarditis virus by the transfer of peritoneal macrophages that were stimulated to produce interferon in vitro by exposure to a nonreplicating virus. This method of therapy was also utilized in animals infected with encephalomy-ocarditis virus after onset of clinical signs. Of these animals 40 percent recovered, but only 9 percent of the control group recovered.

Related Content