Inflammation and Herpes Simplex Virus: Release of a Chemotaxis-Generating Factor from Infected Cells

Science  04 Dec 1970:
Vol. 170, Issue 3962, pp. 1104-1106
DOI: 10.1126/science.170.3962.1104


Infection of primary rabbit kidney cells with herpes simplex virus leads to the release of a cell factor or factors that upon incubation with serum results in the cleavage of the fifth component, C5, of complement. The product of this cleavage, C5a, is chemotactic for polymorphonuclear leukocytes and could be responsible for the accumulation of these cells at the site of herpetic lesions.