Reports

Neuraminidase Activity in HeLa Cells: Effect of Hydrocortisone

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Science  04 Dec 1970:
Vol. 170, Issue 3962, pp. 1110-1112
DOI: 10.1126/science.170.3962.1110

Abstract

Homogenates of HeLa cells contain neuraminidase activity. This enzyme is particle-bound, and it has a pH optimum of 4.2. Hydrocortisone-regulated cells contain two to three times as much neuraminidase as the corresponding controls. The hydrocortisone treatment also causes an increase in the cell content of β-glucuronidase and acid deoxyribonuclease.