Antimalarials: Effects on in vivo and in vitro Protein Synthesis

Science  11 Dec 1970:
Vol. 170, Issue 3963, pp. 1213-1214
DOI: 10.1126/science.170.3963.1213


The antimalarials quinine, chloroquine, primaquine, and quinacrine inhibited the uptake and incorporation of amino acids in vivo, but these drugs had considerably less effect on cell-free protein synthesis. The results indicate that the primary effect of the four drugs on protein synthesis is blocking of amino acid uptake by the cells.