Cell Interaction in an Immune Response in vitro: Requirement for Theta-Carrying Cells

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Science  11 Dec 1970:
Vol. 170, Issue 3963, pp. 1215-1217
DOI: 10.1126/science.170.3963.1215


Cytotoxic antiserum to theta antigen reduces the capacity of mouse spleen cells to generate direct and indirect plaque-forming cells to sheep erythrocytes in vitro but does not affect plaque-forming cells, their precursors, or hemopoietic stem cells. The response of spleen cells treated with antiserum to theta antigen is restored by thymus cells incubated in vivo with sheep erythrocytes.