Reduced Catechol-O-Methyltransferase Activity in Red Blood Cells of Women with Primary Affective Disorder

Science  18 Dec 1970:
Vol. 170, Issue 3964, pp. 1323-1324
DOI: 10.1126/science.170.3964.1323


Red blood cell catechol-O-methyltransferase, histamine-N-methyltransferase, and a methanol-forming enzyme were examined in a number of subjects with mental diseases. Catechol-O-methyltransferase activity was significantly reduced in female subjects with primary affective disorder (depression) as compared to normal women and men, men with primary affective disorder, and schizophrenic men and women. In depressed women, histamine-N-methyltransferase activity was elevated and the methanol-forming enzyme was unchanged.