Cytotoxicity: Specificity after in vitro Sensitization

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Science  25 Dec 1970:
Vol. 170, Issue 3965, pp. 1406-1409
DOI: 10.1126/science.170.3965.1406


Animals sensitized in vivo against an allogeneic tissue subsequently show accelerated rejection specificially of that or antigenically similar tissues. Lymphocytes sensitized in vitro will destroy target cells isogeneic with the sensitizing cells. Lymphocytes sensitized in vitro can differentiate specifically between different allogeneic target cells—as occurs in vivo.