Adenyl Cyclase of Cultured Mammalian Cells: Activation by Catecholamines

Science  25 Dec 1970:
Vol. 170, Issue 3965, pp. 1421-1423
DOI: 10.1126/science.170.3965.1421


Chang's liver cells and 3T6 mouse embryo fibroblasts contain high amounts of catecholamine-sensitive adenyl cyclase, whereas HeLa cells contain relatively low amounts of activity. Both epinephrine and fluoride ion stimulate activity of each cell line. In contrast to normal liver, Chang's liver cells show greater response to epinephrine and no detectable stimulation by glucagon.