Reports

Chemically Induced Porphyria: Increased Microsomal Heme Turnover after Treatment with Allylisopropylacetamide

Science  08 Jan 1971:
Vol. 171, Issue 3966, pp. 64-66
DOI: 10.1126/science.171.3966.64

Abstract

Excessive induction of δ-aminolevulinic acid synthetase in rats after treatment with porphyria-inducing chemicals, such as allylisopropylacetamide, is accompanied by a decrease in microsomal heme and cytochrome P450 concentrations. Measurement of the radioactive decay after labeling of the heme moiety of submicrosomal particles shows increased breakdown of heme in rats treated with allylisopropylacetamide. The effects of allylisopropylacetamide on heme synthesis and heme turnover may be interrelated

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