Carcinogen and Microsomal Membrane Interactions: Changes in Membrane Density and Ability to Bind Nucleic Acids

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Science  15 Jan 1971:
Vol. 171, Issue 3967, pp. 201-203
DOI: 10.1126/science.171.3967.201


DNA and synthetic copolymer polyribocytidylic-polyriboguanylic acid bind to microsomal membrane. The nucleic acid-membrane complex may be detected by centrifugation in cesium chloride density gradients. The density of the nucleic acid-membrane complex and, in certain cases, the amount of nucleic acid associated with the membrane was changed in the presence of various carcinogenic chemicals.