Urinary Adenosine 3',5'-Monophosphate in the Switch Process from Depression to Mania

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Science  22 Jan 1971:
Vol. 171, Issue 3968, pp. 300-303
DOI: 10.1126/science.171.3968.300


Marked elevations of urinary adenosine 3',5'-monophosphate occurred on the day of rapid switch from a depressed into a manic state in patients with manic-depressive illness. It is suggested that this increase might serve a trigger function for the process by which catecholamines are elevated during the manic phase of the illness.