Induction of Liver Acetaldehyde Dehydrogenase: Possible Role in Ethanol Tolerance after Exposure to Barbiturates

Science  29 Jan 1971:
Vol. 171, Issue 3969, pp. 387-389
DOI: 10.1126/science.171.3969.387


Mice were injected twice a day for 4 days with saline or phenobarbital or ethanol. Treatment with phenobarbital, but not ethanol, increased the amount of liver acetaldehyde dehydrogenase activity. More rapid removal of acetaldehyde, which is a toxic metabolic intermediate of ethanol, may contribute to the alcohol tolerance exhibited by persons who use barbiturates regularly.