Age-Associated Changes in the DNA of Mouse Tissue

Science  05 Mar 1971:
Vol. 171, Issue 3974, pp. 917-920
DOI: 10.1126/science.171.3974.917


The template activity of DNA with calf thymus DNA polymerase has been studied in sections of fixed brain, liver, and heart tissues from young and senescent mice. The enzyme catalyzed greater incorporation of deoxyribonucleotide monophosphates into nuclei of old mouse neurons, astrocytes, Kupffer cells, and heart muscle fibers. The results are interpreted as the accumulation of DNA strand breaks with aging.