Reports

Synaptic Transmission in the Crayfish: Increased Release of Transmitter Substance by Bacterial Endotoxin

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Science  19 Mar 1971:
Vol. 171, Issue 3976, pp. 1153-1155
DOI: 10.1126/science.171.3976.1153

Abstract

Bacterial endotoxin increases the frequency of miniature excitatory postsynaptic potentials, decreases facilitation, and increases the evoked excitatory postsynaptic potential without changing membrane resistance. These data indicate that endotoxin acts on the presynaptic nerve terminal by increasing the amount of transmitter substance released in response to an applied stimulus.