Reports

Narcotic Tolerance and Dependence: Lack of Relationship with Serotonin Turnover in the Brain

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Science  19 Mar 1971:
Vol. 171, Issue 3976, pp. 1169-1170
DOI: 10.1126/science.171.3976.1169

Abstract

Serotonin turnover was measured in mouse brain by means of the conversion of radioactivity from labeled tryptophan into serotonin. Animals with a high degree of tolerance to and physical dependence on morphine did not differ from control mice.