Serotonin: Two Different Inhibitory Actions on Snail Neurons

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Science  26 Mar 1971:
Vol. 171, Issue 3977, pp. 1252-1254
DOI: 10.1126/science.171.3977.1252


Serotonin (5-hydroxytryptamine) inhibits snail neurons through two different mechanisms. Whereas on some cells it increases selectively the membrane permeability to chloride ions thus giving rise to a net influx of this ion, on other neurons it increases the permeability to potassium ions causing a net potassium efflux. The serotonin receptors involved in these two inhibitions are different; they also differ from the receptors involved in the excitatory action of serotonin previously described in snail neurons.