Alcohol Dependence and Opiate Dependence: Lack of Relationship in Mice

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Science  16 Apr 1971:
Vol. 172, Issue 3980, pp. 290-292
DOI: 10.1126/science.172.3980.290


According to a recently proposed hypothesis, physical dependence upon alcohol is due to the formation of an endogenous opiate. We tested the hypothesis by determining whether or not ethanol-dependent mice would show typical opiate-dependent behavior (withdrawal jumping syndrome) when challenged with the opiate antagonist naloxone. Our results do not support the hypothesis.