Immunoglobulin Production by Human Lymphocytoid Lines and Clones: Absence of Genic Exclusion

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Science  23 Apr 1971:
Vol. 172, Issue 3981, pp. 382-383
DOI: 10.1126/science.172.3981.382


Immunoglobulin production was studied in established lines of normal human lymphocytes. Three lines which produced both immunoglobulin G and immunoglobulin M were cloned. Among the 25 immunoglobulin-producing clones, 23 produced both classes of immunoglobulins. These findings suggest that the phenomenon of genic exclusion does not hold for immunoglobulin production in lymphocytoid cells in culture.