Striated Muscle Fibers: Facilitation of Contraction at Short Lengths by Caffeine

Science  23 Apr 1971:
Vol. 172, Issue 3981, pp. 387-388
DOI: 10.1126/science.172.3981.387


One of the factors evidently responsible for decreasing the force of muscle contraction with shortening is inactivation of the myofibrils in the core of a muscle fiber. Caffeine antagonizes this inactivation and, correspondingly, changes the length-force relationship at short muscle lengths.