Preganglionic Stimulation Increases Calcium Uptake by Sympathetic Ganglia

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Science  23 Apr 1971:
Vol. 172, Issue 3981, pp. 391-393
DOI: 10.1126/science.172.3981.391


Isolated superior cervical ganglia of rats accumulate more calcium during preganglionic stimulation than do unstimulated controls; uptake of calcium-45 is approximately doubled by stimulation of 12 impulses per second. The extra uptake is markedly reduced by a high concentration of magnesium, but not by mecamylamine hydrochloride or tetraethylammonium chloride, although all three agents eliminate the postsynaptic action potential. Uptake of calcium-45 is also greatly increased by a high external concentration of potassium.