Norepinephrine Biosynthesis Inhibition: Effects on Memory in Mice

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Science  30 Apr 1971:
Vol. 172, Issue 3982, pp. 498-499
DOI: 10.1126/science.172.3982.498


Diethyldithiocarbamate, a dopamine beta hydroxylase inhibitor, decreases biosynthesis of norepinephrine in the brain. The effects of this inhibitor coincide with alterations in memory as demonstrated in single-trial passive avoidance in C57BL/6J mice.