Tumor hnmunity: Tumor Suppression in vivo Initiated by Soluble Products of Specifically Stimulated Lymphocytes

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Science  14 May 1971:
Vol. 172, Issue 3984, pp. 729-731
DOI: 10.1126/science.172.3984.729


Supernatant fluids of specifically stimulated lymphocyte cultures were purified. Fractions containing migration inhibition factor when injected intra-dermally into strain-2 guinea pigs produced a reaction similar in appearance to delayed cutaneous hypersensitivity. There was an accumulation of mononuclear cells at the injection sites and the growth of syngeneic tumor grafts at the sites was suppressed.