Vitamin D3: Induction of Calcium-Binding Protein in Embryonic Chick Intestine in vitro

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Science  14 May 1971:
Vol. 172, Issue 3984, pp. 731-733
DOI: 10.1126/science.172.3984.731


Induction of the synthesis of calcium-binding protein in chick embryonic intestine maintained in vitro was accomplished by simply adding vitamin D3 to the culture medium. Accompanying the induction of this protein, there was enhanced radiocalcium uptake by the intestine. These observations represent the first demonstration of an in vitro physiological effect of vitamin D3 on the calcium absorptive mechanism of the intestine.