L-Glutaminase: Suppression of Lymphocyte Blastogenic Responses in vitro

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Science  14 May 1971:
Vol. 172, Issue 3984, pp. 736-738
DOI: 10.1126/science.172.3984.736


Continuous exposure to 0.1 international unit or more of Escherichia coli L-glutaminase inhibited responses of human lymphocytes to phytohemagglutinin, streptolysin O, and allogeneic leukocytes. Inhibition was completety reversed by removing the enzyme from the culture or adding L-glutamine but not L-asparagine. Cytoxicity did not occur. L-Glutaminase should be immunosuppressive in vivo.