DNA Synthesis and Interaction between Controlled Feeding Schedules and Partial Hepatectomy in Rats

Science  14 May 1971:
Vol. 172, Issue 3984, pp. 738-741
DOI: 10.1126/science.172.3984.738


The rate of DNA synthesis has been measured during liver regeneration in rats adapted to a controlled feeding schedule. The results show two different phenomena in the regulation of DNA synthesis. The first is the appearance of a peak of DNA synthesis following the operation itself and independent of the time of the day; the second one is the presence of constant diurnal variations in the rate of DNA synthesis in response to the partial hepatectomy and following the stimulus or stimuli of the controlled feeding schedule.