Cross-Linked Transfer RNA Functions in All Steps of the Translation Process

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Science  21 May 1971:
Vol. 172, Issue 3985, pp. 854-855
DOI: 10.1126/science.172.3985.854


A specific photochemical reaction between 4-thiouridine and cytosine cross-links two arms of transfer RNA. This cross-link, introduced into phenylalanine transfer RNA and arginine transfer RNA, limits the conformational freedom of the molecule. Both modified transfer RNA's are capable of functioning in all steps of protein synthesis with this restraint on allowable conformations.