Crystal Structure of L-N-Acetylhistidine Monohydrate: An Open and Closed Case

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Science  28 May 1971:
Vol. 172, Issue 3986, pp. 945-946
DOI: 10.1126/science.172.3986.945


L-N-Acetylhistidine crystallizes from aqueous solution as the monohydrate. The crystals are triclinic, space group P1, with two formula units per cell. The structural solution was accomplished by direct methods. The two independent molecules have very different conformations, one open and one closed. These two conformations are compared with those found in other histidine structures.