Lead Suppression of Mouse Resistance to Salmonella typhimurium

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Science  04 Jun 1971:
Vol. 172, Issue 3987, pp. 1031-1032
DOI: 10.1126/science.172.3987.1031


Mice were treated with subclinical doses of lead nitrate for 30 days. Lead-treated mice showed greater susceptibility to challenge with Salmonella typhimurium than controls which received no lead. This result confirms the hypothesis that treatment with lead reduces the resistance of mice to bacterial infection.