Calcium: Is It Required for Transmitter Secretion?

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Science  04 Jun 1971:
Vol. 172, Issue 3987, pp. 1034-1036
DOI: 10.1126/science.172.3987.1034


Ethanol multiplies miniature end-plate potential frequency independently of calcium ion concentrations and also multiplies calcium-dependent depolarization-evoked quantal release, to the same extent. This result implies a final common pathway, requiring little or no calcium, for both kinds of transmitter secretion. Chlorpromazine and hypertonicity act similarly to ethanol, but also depress depolarization-secretion coupling.