Brain Histamine: Rapid Apparent Turnover Altered by Restraint and Cold Stress

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Science  04 Jun 1971:
Vol. 172, Issue 3987, pp. 1037-1039
DOI: 10.1126/science.172.3987.1037


Histamine content of rat brain was lowered quickly by inhibitors of histidine decarboxylase, suggesting that a portion of brain histamine turns over rapidly. Restraint and exposure to cold also reduced brain histamine levels and markedly augmented its formation in the hypothalamus.