Urea Cycle Enzyme Adaptation to Dietary Protein in Primates

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Science  04 Jun 1971:
Vol. 172, Issue 3987, pp. 1042-1043
DOI: 10.1126/science.172.3987.1042


Activities of the five hepatic enzymes of the urea cycle increased two- to threefold in monkeys on a 60 percent protein diet compared with levels in monkeys on an isocaloric 6 percent protein diet. Equal adaptation occurred in rats on the same diets. These enzyme activities in adult humans approximate those of monkeys on a similar protein intake.