Immune Response Restoration with Macrophage Culture Supernatants

Science  04 Jun 1971:
Vol. 172, Issue 3987, pp. 1047-1048
DOI: 10.1126/science.172.3987.1047


Depression of the in vitro immune response of mouse spleen cell suspensions to sheep erythrocytes by removal of macrophages can be reversed by the addition of supernatants from peritoneal macrophage cultures. Supernatant activity can be absorbed by the red cell antigen, and supernatant-treated red cells are stimulatory in the absence of macrophages or supernatant.