Transport of Nitrogen Mustard on the Transport-Carrier for Choline in L5178Y Lymphoblasts

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Science  11 Jun 1971:
Vol. 172, Issue 3988, pp. 1148-1149
DOI: 10.1126/science.172.3988.1148


The uptake of choline by L5178Y lymphoblasts occurs by a carrier mechanism and is an active process. Transport of nitrogen mustard and its hydrolyzed derivative is mediated by this same carrier. This finding is an example of drug transport by a carrier whose primary function is transport of a naturally occurring substrate.