Amyloid Fibril Proteins: Proof of Homology with Immunoglobulin Light Chains by Sequence Analyses

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Science  11 Jun 1971:
Vol. 172, Issue 3988, pp. 1150-1151
DOI: 10.1126/science.172.3988.1150


The sequences of the 35 and 36 amino-terminal amino acids of two purified amyloid fibril proteins have been determined. Results indicate that these two proteins are derived from homogeneous immunoglobulin light chains of variable region subgroup VκI. The relation between amyloidosis and immunoglobulins is thus more firmly established.