Thyrocalcitonin: Stimulation of Secretion by Pentagastrin

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Science  18 Jun 1971:
Vol. 172, Issue 3989, pp. 1238-1240
DOI: 10.1126/science.172.3989.1238


Administration of a small dose of pentagastrin, a synthetic pentapeptide containing the biologically active portion of the native hormone gastrin, results in a marked, rapid, transitory increase in thyrocalcitonin secretion in the pig. Gastrin or a related gastrointestinal peptide may be important in the physiological secretion of thyrocalcitonin, such as that which occurs when calcium salts are introduced into the gastrointestinal tract.