Cell-Surface Changes after Infection with Oncogenic Viruses: Requirement for Synthesis of Host DNA

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Science  25 Jun 1971:
Vol. 172, Issue 3990, pp. 1345-1346
DOI: 10.1126/science.172.3990.1345


The change in the surface structure of cultutred mammalian cells infected with oncogenic DNA viruses was similar to that described for the fully and permanently transformed cell surfaces. The course of appearance of this change was established. Synthesis of host DNA is required for expression of the surface change triggered by infection with the oncogenic virus.