Rubidium and Lithium: Opposite Effects on Amine-Mediated Excitement

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Science  25 Jun 1971:
Vol. 172, Issue 3990, pp. 1355-1357
DOI: 10.1126/science.172.3990.1355


In mice the activation caused by morphine was antagonized by previous treatment with lithium and was potentiated by previous treatment with rubidium. Other antimanic drugs antagonized the morphine activation as well. The effect of rubidium was similar to that of the antidepressant drugs imipramine and pargyline. Rubidium may merit clinical evaluation as an antidepressant agent in man.