Teratogenic Effects of a Chelating Agent and Their Prevention by Zinc

Science  02 Jul 1971:
Vol. 173, Issue 3991, pp. 62-64
DOI: 10.1126/science.173.3991.62


Ingestion of a chelating agent (ethylenediaminetetraacetic acid) by female rats during pregnancy impaired reproduction and resulted in congenitally malformed young. When ethylenediaminetetraacetic acid was fed from days 6 to 21 of gestation, all of the full-term young had gross congenital malformations. These effects were prevented by simultaneous supplementation with 1000 parts per million of dietary zinc.