Nuclear Localization of Histamine in Neonatal Rat Brain

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Science  16 Jul 1971:
Vol. 173, Issue 3993, pp. 247-249
DOI: 10.1126/science.173.3993.247


The concentration of histamine in the brains of neonatal rats is considerably higher than that in adults. Subcellular fractionation studies revealed that about 90 percent of the histamine content of neonatal rat brain is confined to the crude nuclear fraction obtained by differential fractionation. Purified nuclei prepared from these fractions retained 90 percent of their histamine content. The nuclear localization of histamine in the brains of neonatal rats suggests a function for histamine in modulating the growth processes of the neonatal brain.