Acetoxycycloheximide Enhances Audiogenic Seizures in DBA/2J Mice

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Science  16 Jul 1971:
Vol. 173, Issue 3993, pp. 249-251
DOI: 10.1126/science.173.3993.249


Inborn errors of metabolism often cause epilepsy, as with certain strains of mice. Aggravating the metabolic defect with a protein synthesis inhibitor increases the symptoms. Mature animals that have "outgrown" their genetic susceptibility to audiogenic seizures are made susceptible again by acetoxycycloheximide. After a single small dose the incidence and severity of audiogenic seizures increases at 16 hours, reaches a maximum of 40 hours, and then declines gradually.